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Valtrex vs generic valacyclovir, valacyclovir famciclovir, and vs ciclovir. The trial was stopped early for one trial out of 6,637 patients (1/1253). Two other treatment arms were evaluated at one time point in a separate analysis. The primary efficacy end point was one of two end points measured in the primary analysis: ≥20 mg of valacyclovir once daily (0.5-6 mg of valacyclovir) for 5 days or ≥1 g of famciclovir once daily (0.5-4 g of famciclovir) for 5 days to prevent at least two episodes of herpes zoster, or to treat a herpes zoster episode for 3 or more consecutive days. Both groups had identical rates of herpes zoster-related hospitalizations. Efficacy was achieved at two sites (one in the valacyclovir group and one in the famciclovir group). HIV Infection: Nine (0.1%) of 6,669 patients were HIV-infected at all time points. Nine participants in the valacyclovir arm received antiretroviral therapy at all time points (11/1,058 in the valacyclovir group and 3/066 in the famciclovir arm). In the multivariate analysis, presence of HIV did not affect treatment outcomes except for the primary analysis where participants receiving therapy at any time point were associated with reduced risk of herpes zoster (risk ratio [RR], 0.67 [95% CI, 0.46-0.98]), herpes infection (RR, 0.73 [95% CI, 0.46-1.05]), or atopic dermatitis (RR, 0.71 [95% CI, 0.45-1.05]). Other Laboratory Data: The total CD4 percentage was similar for both valacyclovir and famciclovir groups, but less than half had detectable levels of HIV RNA (47.8% valacyclovir generic ranbaxy for both groups). Statistically significant differences in the risk of herpes zoster were present at weeks 3 (n=10); 14 (n=15); 17 (n=16); 24 (n=16), 31 (n=16) and 39 but did not reach significance with the use of multiple logistic regression model for all time points after the first. However, risk of herpes zoster at each time point was reduced with the use of family-based logistic regression model (RR, 0.65 [95% CI, 0.45-0.98]). This model included age and duration of study accounted for covariates sex, type of contraception, baseline CD4 count, and HLA classification. The risk of treatment failure increased with increasing duration in the valacyclovir group (relative risk, 1.29; 95% CI, 1.11-1.51). No such increase was observed in the famciclovir group. The risk of treatment failure was not increased when using the combined antiretroviral therapy group (RR, 1.20; 95% CI, 0.98-1.42). No statistically significant association for zoster was found between plasma HIV RNA concentration (baseline, n=18; week 0 to 3, n=17; 4)

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